1363467-46-2Relevant academic research and scientific papers
Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives
Jagu, Elodie,Pomel, Sébastien,Diez-Martinez, Alba,Rascol, Estelle,Pethe, Stéphanie,Loiseau, Philippe M.,Labruère, Rapha?l
, p. 655 - 666 (2018)
This study describes the synthesis and the biological evaluation of twenty-four original bis(benzyl)spermidines. Structural modifications of the polyamine scaffold were performed in order to avoid easily metabolized bonds. Some bis(benzyl)polyamine derivatives have demonstrated promising activity in vitro against Trypanosoma brucei gambiense and Leishmania donovani. From the enzymatic experiments on trypanothione reductase, we observed that this enzyme was not targeted by our compounds. In vivo evaluation on Swiss mice model infected by T. b. gambiense or L. donovani was done with the most interesting compound of the series.
NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
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, (2021/11/13)
Compounds of formula (I): wherein R, X1, X2, X3, Z1, Z2, Z3, A and Ra are as defined in the description. Medicaments.
Efficient synthesis of the siderophore petrobactin via antimony triethoxide mediated coupling
Pandey, Rajesh K.,Jarvis, Gregory G.,Low, Philip S.
scheme or table, p. 1627 - 1629 (2012/04/17)
Chemical synthesis of petrobactin, a siderophore for Bacillus anthracis, has been achieved via Sb(OEt)3-mediated ester-amide exchange.
