Technology Process of (R)-(3-bromo-phenyl)-naphthalen-1-yl-methanol
There total 6 articles about (R)-(3-bromo-phenyl)-naphthalen-1-yl-methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-Bromo-3-iodobenzene;
With
cyclopentylmagnesium chloride;
In
diethyl ether;
at 0 ℃;
for 2h;
Inert atmosphere;
With
titanium(IV) isopropylate;
In
diethyl ether; dichloromethane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
1-naphthaldehyde;
optical yield given as %ee;
enantioselective reaction;
Further stages;
DOI:10.1246/bcsj.20090232
- Guidance literature:
-
1,3-dibromobenzene;
With
TurboGrignard;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
Inert atmosphere;
1-naphthaldehyde;
With
titanium(IV) isopropylate; (R)-3-(3,5-diphenylphenyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl;
In
diethyl ether; dichloromethane;
at -15 ℃;
for 3h;
Inert atmosphere;
With
hydrogenchloride; water;
In
diethyl ether; dichloromethane;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1055/s-0031-1289854
- Guidance literature:
-
3-bromophenyl magnesium bromide;
With
titanium(IV) isopropylate;
In
diethyl ether; dichloromethane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
1-naphthaldehyde;
With
titanium(IV) isopropylate;
In
dichloromethane;
at 0 ℃;
for 5h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/acs.orglett.8b00945
