methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate

Base Information

• Chemical Name: methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate
• CAS No.: 500794-86-5
• Molecular Formula: C₂₀H₂₁Br₂IO₄
• Molecular Weight: 612.097
• Mol file: 500794-86-5.mol

Synonyms:methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate

Chemical Property of methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate

There total 1 articles about methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methyl 3-[3,5-dibromo-4-(3-amino-5-isopropyl-4-methoxyphenoxy)phenyl]propionate hydrochloride → methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate (500794-86-5)

Guidance literature:

methyl 3-[3,5-dibromo-4-(3-amino-5-isopropyl-4-methoxyphenoxy)phenyl]propionate hydrochloride; With hydrogenchloride; sodium nitrite; In methanol; at -20 - -15 ℃; for 0.666667h;

With potassium iodide; In methanol; water; at -15 - 5 ℃; for 2h;

DOI:10.1021/jm060521i

Reference yield: 83.0%

methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate (500794-86-5) → methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-hydroxyphenoxy)phenyl]propionate (500794-91-2)

Guidance literature:

With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃;

DOI:10.1021/jm060521i

Reference yield:

methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-methoxyphenoxy)phenyl]propionate (500794-86-5) → 3-{3,5-dibromo-4-[4-hydroxy-3-isopropyl-5-(2-pyridin-4-yl-vinyl)-phenoxy]-phenyl}-propionic acid (500794-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / BF₃*SMe₂ / CH₂Cl₂ / 20 °C

2: 62 percent / diisopropylethylamine; LiCl; Pd(OAc)2 / dimethylformamide / 75 °C

3: 94 percent / aq. LiOH / tetrahydrofuran / 20 °C

With palladium diacetate; lithium hydroxide; boron dimethyl-trifluoro sulphide; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm060521i

Downstream raw materials:

methyl 3-[3,5-dibromo-4-(3-iodo-5-isopropyl-4-hydroxyphenoxy)phenyl]propionate

3-{3,5-dibromo-4-[4-hydroxy-3-isopropyl-5-(2-pyridin-4-yl-vinyl)-phenoxy]-phenyl}-propionic acid

methyl 3-{3,5-dibromo-4-[4-hydroxy-3-isopropyl-5-((E)-2-pyridin-4-yl-vinyl)phenoxy]phenyl}propionate