N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

Base Information

Chemical Name:N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide
CAS No.:1321468-64-7
Molecular Formula:C₂₂H₂₂N₆O₂
Molecular Weight:402.456
Hs Code.:

Synonyms:N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

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Chemical Property of N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

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Technology Process of N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

There total 6 articles about N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.2%

: 1321468-61-4
N-ethyl-N-(3-pyridylmethyl)-2-(8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

: 74-88-4
methyl iodide

: 1321468-64-7
N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 5h;
DOI:10.1021/jm200516a

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 1321468-64-7
N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 10 h / 20 °C

2: sodium tetrahydroborate / ethanol / 12 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium hydroxide / ethanol / 12 h / 20 °C

5: diphenyl phosphoryl azide; triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C

6: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 50 °C

With sodium tetrahydroborate; diphenyl phosphoryl azide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200516a

Reference yield:

: 3000-75-7
N-ethyl-N-(3-pyridylmethyl)amine

: 1321468-64-7
N-ethyl-N-(3-pyridylmethyl)-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2: sodium hydroxide / ethanol / 12 h / 20 °C

3: diphenyl phosphoryl azide; triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 50 °C

With diphenyl phosphoryl azide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200516a