2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol

Base Information

• Chemical Name: 2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol
• CAS No.: 1020840-26-9
• Molecular Formula: C₁₇H₁₂ClN₃O
• Molecular Weight: 309.755
• Mol file: 1020840-26-9.mol

Synonyms:2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol

Chemical Property of 2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

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Technology Process of 2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol

There total 1 articles about 2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.7%

6-chloro-3-iodo-4H-chromen-4-one (73220-39-0) + 4-Ethynylaniline (14235-81-5) → 2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol (1020840-26-9)

Guidance literature:

6-chloro-3-iodo-4H-chromen-4-one; 4-Ethynylaniline; With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 20 ℃; for 7h;

With hydrazine; In acetonitrile; at 20 ℃;

Reference yield: 71.3%

(S)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid (783350-37-8) + 2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol (1020840-26-9) → 3(S)-{4-[3-(5-chloro-2-hydroxy-phenyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester (1020840-35-0)

Guidance literature:

(S)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid; 2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol; With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

Reference yield: 57.2%

2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol (1020840-26-9) + (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → 2(S)-{4-[3-(5-chloro-2-hydroxy-phenyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester (1020840-28-1)

Guidance literature:

2-[4-(4-amino-phenylethynyl)-1H-pyrazol-3-yl]-4-chloro-phenol; (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid; With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

upstream raw materials:

6-chloro-3-iodo-4H-chromen-4-one

4-Ethynylaniline

Downstream raw materials:

2(S)-{4-[3-(5-chloro-2-hydroxy-phenyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-piperidine-1-carboxylic acid tert-butyl ester

3(S)-{4-[3-(5-chloro-2-hydroxy-phenyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester