(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Base Information

Chemical Name:(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester
CAS No.:175551-73-2
Molecular Formula:C₄₂H₅₅Cl₃N₂O₇Si
Molecular Weight:834.352
Hs Code.:

(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Synonyms:(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Suppliers and Price of (R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

There total 18 articles about (R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 175551-79-8
(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-8-hydroxy-4-methyl-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

: 175551-73-2
(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Guidance literature:: With Dess-Martin periodane; In dichloromethane; Ambient temperature;
DOI:10.1021/ja954311z

Reference yield:

: 103027-05-0
(E)-(4R,5R)-5-Hydroxy-4,6-dimethyl-hept-2-enal

: 175551-73-2
(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / DCC, DMAP / CH₂Cl₂

2: 88 percent / NH₂SO₃H, NaClO₂ / tetrahydrofuran; H₂O / 0 °C

3: 89 percent / 2-chloro-1-methylpyridinium iodide, n-Bu₃N / CH₂Cl₂ / Ambient temperature

4: 82 percent / 70percent HF, pyridine / tetrahydrofuran / 0 °C

5: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

With pyridine; dmap; sodium chlorite; tributyl-amine; aminosulfonic acid; hydrogen fluoride; 2-chloro-1-methyl-pyridinium iodide; Dess-Martin periodane; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja954311z

Reference yield:

: 175551-59-4
(E)-3-[(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-pent-2-enoic acid methyl ester

: 175551-73-2
(R)-Pyrrolidine-1,2-dicarboxylic acid 2-{(E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl} ester 1-(2,2,2-trichloro-ethyl) ester

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / LDA / tetrahydrofuran / -78 - 0 °C

2: 92 percent / Li, NH₃, t-BuOH / tetrahydrofuran

3: 1.) m-CPBA, 2.) pyridine / 1.) THF, -78 deg C, 2.) 0 deg C

4: 92 percent / DCC, DMAP / CH₂Cl₂

5: 88 percent / NH₂SO₃H, NaClO₂ / tetrahydrofuran; H₂O / 0 °C

6: 89 percent / 2-chloro-1-methylpyridinium iodide, n-Bu₃N / CH₂Cl₂ / Ambient temperature

7: 82 percent / 70percent HF, pyridine / tetrahydrofuran / 0 °C

8: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

With pyridine; dmap; sodium chlorite; tributyl-amine; aminosulfonic acid; hydrogen fluoride; 2-chloro-1-methyl-pyridinium iodide; ammonia; lithium; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; tert-butyl alcohol; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja954311z