(4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one

Base Information

• Chemical Name: (4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one
• CAS No.: 151062-79-2
• Molecular Formula: C₁₇H₂₂N₂O₂
• Molecular Weight: 286.374
• Mol file: 151062-79-2.mol

Synonyms:(4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one

Chemical Property of (4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one

There total 1 articles about (4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(E)-2-hexenoyl chloride (97943-16-3) + (4R,5S)-3,4-dimethyl-5-phenyl-imidazolidin-2-one (112791-04-5) → (4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one (151062-79-2)

Guidance literature:

With methylmagnesium chloride; In tetrahydrofuran; 1.) 30 min, 2.) 25 deg C, 1 h;

DOI:10.1021/jo00073a017

Reference yield:

N-benzyloxyamine (622-33-3) + (4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one (151062-79-2) → (4R,5S)-1-((S)-3-Benzyloxyamino-hexanoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one + (4R,5S)-1-((R)-3-Benzyloxyamino-hexanoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 ℃; Product distribution; other Lewis acids;

DOI:10.1021/jo00073a017

Reference yield:

phthalimide (136918-14-4,85-41-6) + (4R,5S)-1-((E)-Hex-2-enoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one (151062-79-2) → 2-{(R)-1-[(S)-1-Bromo-2-((4R,5S)-3,4-dimethyl-2-oxo-5-phenyl-imidazolidin-1-yl)-2-oxo-ethyl]-butyl}-isoindole-1,3-dione

Guidance literature:

With isopropylmagnesium chloride; benzenesulfonyl bromide; Yield given. Multistep reaction; 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C - room t., 72 h;

DOI:10.1016/S0040-4039(00)73317-X

upstream raw materials:

(E)-2-hexenoyl chloride

(4R,5S)-3,4-dimethyl-5-phenyl-imidazolidin-2-one