N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

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Chemical Name:N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide
CAS No.:1443237-19-1
Molecular Formula:C₁₉H₁₅N₅O₂
Molecular Weight:345.36
Hs Code.:

Synonyms:N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

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Chemical Property of N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

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Technology Process of N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

There total 7 articles about N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443237-75-9
N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

: 1443237-19-1
N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

Guidance literature:: N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide; With trifluoroacetic acid; In dichloromethane; at 50 ℃; for 1h; Inert atmosphere;

With ethylenediamine; sodium hydroxide; In methanol; at 15 - 25 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1443237-70-4
3-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

: 1443237-19-1
N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -5 - 25 °C

2.1: N-Bromosuccinimide / acetonitrile / 2 h / 80 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 60 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1 h / 50 °C / Inert atmosphere

4.2: 0.5 h / 15 - 25 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; XPhos; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 941685-26-3
4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1443237-19-1
N-(3-(5-(oxazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / methanol / 15 - 25 °C / 760.05 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -5 - 25 °C

4.1: N-Bromosuccinimide / acetonitrile / 2 h / 80 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 60 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h / 50 °C / Inert atmosphere

6.2: 0.5 h / 15 - 25 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; XPhos; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;