N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

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Chemical Name:N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide
CAS No.:1443237-75-9
Molecular Formula:C₂₅H₂₉N₅O₃Si
Molecular Weight:475.622
Hs Code.:

Synonyms:N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

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Chemical Property of N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

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Technology Process of N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

There total 7 articles about N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443237-72-6
N-(3-(5-bromo-7-(((2-trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

: 145214-05-7
2-(tributyltin)oxazole

: 1443237-75-9
N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In toluene; at 60 ℃; Inert atmosphere;

Reference yield:

: 941685-26-3
4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1443237-75-9
N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 15 - 25 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / -5 - 25 °C

4: N-Bromosuccinimide / acetonitrile / 2 h / 80 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 60 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1443237-70-4
3-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)aniline

: 1443237-75-9
N-(3-(5-(oxazol-2-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)methacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / -5 - 25 °C

2: N-Bromosuccinimide / acetonitrile / 2 h / 80 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 60 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; N-ethyl-N,N-diisopropylamine; XPhos; In dichloromethane; toluene; acetonitrile;