5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine

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Chemical Name:5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine
CAS No.:1361188-49-9
Molecular Formula:C₂₀H₁₉N₇O
Molecular Weight:373.417
Hs Code.:

Synonyms:5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine

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Chemical Property of 5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine

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Technology Process of 5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine

There total 4 articles about 5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59489-71-3
5-amino-2-bromopyrazine

: 1361190-19-3
5-(1-methyl-1H-pyrazol-4-yl)-3-{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazole

: 1361188-49-9
5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere; Sealed vial;

Reference yield:

: 485828-58-8
1-(4- bromophenyl)cyclobutane-1-carbonitrile

: 1361188-49-9
5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine / ethanol; water / 80 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 50 °C

2.2: 1 h / 150 °C / Microwave irradiation

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 100 °C / Sealed vial; Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 18 h / 100 °C / Inert atmosphere; Sealed vial

With hydroxylamine; potassium acetate; sodium carbonate; 1,1'-carbonyldiimidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1361189-45-8
1-(4-bromophenyl)-N-hydroxycyclobutanecarboxamidine

: 1361188-49-9
5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 50 °C

1.2: 1 h / 150 °C / Microwave irradiation

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 100 °C / Sealed vial; Inert atmosphere

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 18 h / 100 °C / Inert atmosphere; Sealed vial

With potassium acetate; sodium carbonate; 1,1'-carbonyldiimidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;