(4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone

Base Information

Chemical Name:(4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone
CAS No.:159588-97-3
Molecular Formula:C₂₃H₃₁N₅O
Molecular Weight:393.532
Hs Code.:

(4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[<i>b</i>][1,4]diazepin-1-yl}-methanone

Synonyms:(4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone

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Chemical Property of (4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone

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Technology Process of (4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone

There total 7 articles about (4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 159588-88-2
{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-(4-nitro-phenyl)-methanone

: 159588-97-3
(4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.46.1566

Reference yield:

: 109-01-3
1-methyl-piperazine

: 159588-97-3
(4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / WSC, HOBt / tetrahydrofuran / 18 h / Ambient temperature

2: 91 percent / BH₃*THF / tetrahydrofuran / 7 h / Heating

3: 43 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 5 °C

4: 100 percent / H₂ / 10 percent Pd/C / acetic acid / 760 Torr / Ambient temperature

With borane-THF; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1248/cpb.46.1566

Reference yield:

: 5755-07-7
2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

: 159588-97-3
(4-amino-phenyl)-{5-[2-(4-methyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, from 0 deg C to 20 deg C, 40 min, 2.) DMF, from 0 deg C to 5 deg C, 30 min

2: 19 percent / 1 N NaOH / ethanol / 3 h / Ambient temperature

3: 65 percent / WSC, HOBt / tetrahydrofuran / 18 h / Ambient temperature

4: 91 percent / BH₃*THF / tetrahydrofuran / 7 h / Heating

5: 43 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 5 °C

6: 100 percent / H₂ / 10 percent Pd/C / acetic acid / 760 Torr / Ambient temperature

With sodium hydroxide; borane-THF; hydrogen; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1248/cpb.46.1566