5755-07-7

Basic information

• Product Name: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE
• Synonyms: 1,2,3,5-tetrahydro-1,5-benzodiazepin-4-one
• CAS NO: 5755-07-7
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• Product Categories: Aromatics;Heterocycles
• Mol File: 5755-07-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 140.5-141.5 °C
• Boiling Point: 376.1°Cat760mmHg
• Flash Point: 178.7°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 7.45E-06mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.80±0.20(Predicted)
• CAS DataBase Reference: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE(5755-07-7)
• EPA Substance Registry System: 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONE(5755-07-7)

Safety Data

• Hazardous Substances Data: 5755-07-7(Hazardous Substances Data)

Usage

Uses

A tetrahydrobenzodiazepine derivative as arginine vasopressin antagonist.

InChI:InChI=1/C9H10N2O/c12-9-5-6-10-7-3-1-2-4-8(7)11-9/h1-4,10H,5-6H2,(H,11,12)

Upstream product

• 930-21-2 2-azetidinone 
• 615-43-0 2-iodophenylamine 
• 615-36-1 2-bromoaniline 
• 4295-36-7 2,3-dihydroquinolin-4(1H)-one 

Downstream Products

• 104310-01-2 5-formyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 
• 104310-03-4 5-(3,4,5-Trimethoxybenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 
• 7647-01-0 hydrogenchloride 
• 65533-78-0 1-nitroso-2,3-dihydro<1,5>benzodiazepin-4-one 
• 120337-33-9 1-Ethyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 309720-57-8 5-benzoyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one 
• 1470407-06-7 N-{3-[(5-benzoyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)carbonyl]-4-nitrophenyl}acetamide 
• 1470407-00-1 5-benzoyl-6,7-dihydroquinazolino[3,2-a][1,5]benzodiazepin-13(5H)-one 
• 1470406-91-7 5-benzoyl-1-(2-nitrobenzoyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one 
• 1296194-40-5 5-benzoyl-1-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one 
• 1296194-47-2 N-{4-[(5-methyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)carbonyl]phenyl}-2-methylbenzamide 
• 175150-82-0 C₂₃H₂₆N₂O₂ 
• 175150-83-1 C₂₄H₂₂N₂O₃ 
• 119483-59-9 5-Benzyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carbaldehyde 

Relevant articles and documents

Synthesis of Medium Ring Nitrogen Heterocycles via a Tandem Copper-Catalyzed C-N Bond Formation-Ring-Expansion Process

A simple method for the preparation of medium ring heterocycles (7-, 8-, 9-, and 10-membered) has been developed. The process employs a Cu-catalyzed coupling of a β-lactam with an aryl bromide or iodide followed by intramolecular attack of a pendant amino group. In some instances, the intermediate β-lactam is observable but can be converted to the aza-heterocycle by catalysis. Acetic acid was found to be superior to transition metal complexes as a catalyst for this ring-expansion process.