(3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

Base Information

Chemical Name:(3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid
CAS No.:251651-02-2
Molecular Formula:C₂₄H₃₀O₆
Molecular Weight:414.499
Hs Code.:

Synonyms:(3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

Suppliers and Price of (3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

There total 15 articles about (3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 251651-01-1
((2R,3S,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-2-hydroxymethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]inden-3-yl)-acetic acid methyl ester

: 251651-02-2
(3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

Guidance literature:: DOI:10.1021/ja992315o

Reference yield:

: (R)-2-[(E)-3-(Dimethyl-phenyl-silanyl)-allyl]-5-methyl-cyclohex-2-enone

: 251651-02-2
(3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 15 steps

1.1: CuI

2.1: NaI; mCPBA

3.1: 82 percent / Bu₃SnH; AIBN / benzene / Heating

4.1: Li; NH₃

5.1: TBAF

5.2: KHCO₃; H₂O₂ / methanol

6.1: 95 percent / imidazole

7.1: 90 percent / PCC

8.1: 88 percent / L-Selectride

9.1: 87 percent / KH / tetrahydrofuran

10.1: 82 percent / CF₃COOH

11.1: SeO₂ / dioxane

13.1: LiClO₄ / diethyl ether / 20 °C

14.1: aq. AcOH / tetrahydrofuran

15.1: 86 percent

With 1H-imidazole; copper(l) iodide; selenium(IV) oxide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; ammonia; tri-n-butyl-tin hydride; lithium perchlorate; lithium; potassium hydride; L-Selectride; acetic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; benzene; 1.1: addition; silylation / 2.1: Iodination / 3.1: Cyclization / 4.1: Reduction / 5.1: Substitution / 5.2: Oxidation / 6.1: silylation / 7.1: Oxidation / 8.1: Reduction / 9.1: benzylation / 10.1: desilylation / 11.1: allylic oxidation / 12.1: Swern oxidation / 13.1: Addition / 14.1: desilylation / 15.1: Jones oxidation;
DOI:10.1021/ja992315o

Reference yield:

: 251650-95-0
(2S,5aR,7R,9R,9aS)-2-Hydroxymethyl-7-methyl-3-trimethylsilanyl-2,4,5,5a,6,7,8,9-octahydro-1H-cyclopenta[c]inden-9-ol

: 251651-02-2
(3R,3aR,5aS,7R,9S,9aS)-9-Benzyloxy-3-methoxycarbonylmethyl-7-methyl-4-oxo-decahydro-cyclopenta[c]indene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / imidazole

2: 90 percent / PCC

3: 88 percent / L-Selectride

4: 87 percent / KH / tetrahydrofuran

5: 82 percent / CF₃COOH

6: SeO₂ / dioxane

8: LiClO₄ / diethyl ether / 20 °C

9: aq. AcOH / tetrahydrofuran

10: 86 percent

With 1H-imidazole; selenium(IV) oxide; lithium perchlorate; potassium hydride; L-Selectride; acetic acid; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; 1: silylation / 2: Oxidation / 3: Reduction / 4: benzylation / 5: desilylation / 6: allylic oxidation / 7: Swern oxidation / 8: Addition / 9: desilylation / 10: Jones oxidation;
DOI:10.1021/ja992315o