1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

Base Information

• Chemical Name: 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide
• CAS No.: 1660148-11-7
• Molecular Formula: C₁₉H₁₂F₃N₃O
• Molecular Weight: 355.319
• Mol file: 1660148-11-7.mol

Synonyms:1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

Chemical Property of 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

There total 5 articles about 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(E)-1-phenyl-5-(phenylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime (1660148-08-2) → 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide (1660148-11-7)

Guidance literature:

With silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.3762/bjoc.10.183

Reference yield: 30.0%

(E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine (1660148-14-0) + phenylacetylene (536-74-3) → 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide (1660148-11-7)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Microwave irradiation;

DOI:10.3762/bjoc.10.183

Reference yield:

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (96145-98-1) → 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide (1660148-11-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 4.5 h / 95 °C

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 1 h / 20 °C

3: palladium diacetate; triphenylphosphine; potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C / Microwave irradiation

With hydroxylamine hydrochloride; sodium acetate; palladium diacetate; potassium carbonate; triphenylphosphine; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

DOI:10.3762/bjoc.10.183

upstream raw materials:

(E)-1-phenyl-5-(phenylethynyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde oxime

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole

(E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine

phenylacetylene