(E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine

Base Information

• Chemical Name: (E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine
• CAS No.: 1660148-14-0
• Molecular Formula: C₁₁H₇ClF₃N₃O
• Molecular Weight: 289.644
• Mol file: 1660148-14-0.mol

Synonyms:(E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine

Chemical Property of (E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine

There total 2 articles about (E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde (318288-78-7) → (E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine (1660148-14-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 20 ℃; for 1h;

DOI:10.3762/bjoc.10.183

Reference yield:

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (96145-98-1) → (E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine (1660148-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 4.5 h / 95 °C

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 1 h / 20 °C

With hydroxylamine hydrochloride; sodium acetate; trichlorophosphate; In ethanol;

DOI:10.3762/bjoc.10.183

Reference yield: 30.0%

(E)-1-[5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-hydroxymethanimine (1660148-14-0) + phenylacetylene (536-74-3) → 1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide (1660148-11-7)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Microwave irradiation;

DOI:10.3762/bjoc.10.183

upstream raw materials:

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole

5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde

Downstream raw materials:

1,6-diphenyl-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide

1-phenyl-6-(3-thienyl)-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine 5-oxide