2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester

Base Information

• Chemical Name: 2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester
• CAS No.: 1239508-87-2
• Molecular Formula: C₁₆H₂₆O₅
• Molecular Weight: 298.379
• Mol file: 1239508-87-2.mol

Synonyms:2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester

Chemical Property of 2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester

There total 3 articles about 2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diethyl ethylidenemalonate (1462-12-0) + cyclohexanecarbaldehyde (2043-61-0) → 2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester (1239508-87-2)

Guidance literature:

With (di-p-tert-butylbenzoxyiodo)benzene; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere; Irradiation;

DOI:10.1002/anie.201406513

Reference yield: 89.0%

diethyl ethylidenemalonate (1462-12-0) + carbon monoxide (201230-82-2) + potassium [18-crown-6] bis(catecholato)cyclohexylsilicate → 2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester (1239508-87-2)

Guidance literature:

With potassium dihydrogenphosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; In N,N-dimethyl-formamide; at 20 ℃; for 48h; under 60006 Torr; Autoclave; Irradiation;

DOI:10.1002/anie.201811858

Reference yield:

diethyl ethylidenemalonate (1462-12-0) + cyclohexanecarbaldehyde (2043-61-0) → 2-(2-cyclohexyl-1-methyl-2-oxoethyl)malonic acid diethyl ester (1239508-87-2) + 2-(1-Cyclohexylethyl)-propandisaeure-diethylester (97311-75-6)

Guidance literature:

With [bis(3,5-di-tert-butylbenzoyloxy)iodo]benzene; In acetonitrile; at 20 ℃; for 12h; Overall yield = 40 %Spectr.; chemoselective reaction; UV-irradiation;

DOI:10.1016/j.tet.2017.08.018

upstream raw materials:

diethyl ethylidenemalonate

cyclohexanecarbaldehyde

carbon monoxide