(S)-(+)-2-CHLOROPHENYLGLYCINE METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: (S)-(+)-2-CHLOROPHENYLGLYCINE METHYL ESTER HYDROCHLORIDE
• CAS No.: 213018-92-9
• Molecular Formula: C9H10 Cl N O2 . Cl H
• Molecular Weight: 236.098
• Hs Code.: 2922499990
• Mol file: 213018-92-9.mol

Synonyms:Benzeneaceticacid, a-amino-2-chloro-, methyl ester,hydrochloride, (aS)- (9CI);(+)-(S)-Methyl a-amino-a-(2-chlorophenyl)acetate hydrochloride; Methyl(2S)-amino(2-chlorophenyl)acetate hydrochloride

Chemical Property of (S)-(+)-2-CHLOROPHENYLGLYCINE METHYL ESTER HYDROCHLORIDE

Chemical Property:

• PSA: 38.33000
• LogP: 2.79990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

methyl(S)-2-amino-2-(2-chlorophenyl)acetatehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(+)-2-CHLOROPHENYLGLYCINE METHYL ESTER HYDROCHLORIDE

There total 2 articles about (S)-(+)-2-CHLOROPHENYLGLYCINE METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate (141109-14-0) → (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt (213018-92-9,212838-70-5)

Guidance literature:

With hydrogenchloride; at 0 - 5 ℃;

Reference yield: 70.0%

→ (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride (141109-18-4,141109-19-5) + (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt (213018-92-9,212838-70-5)

Guidance literature:

Reference yield: 92.0%

2-(2-thienyl)ethyl tosylate (40412-06-4) + (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt (213018-92-9,212838-70-5) → (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride (141109-18-4,141109-19-5)

Guidance literature:

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt; With sodium carbonate; In water; at 20 ℃; Green chemistry;

2-(2-thienyl)ethyl tosylate; With dipotassium hydrogenphosphate; In water; at 70 - 95 ℃; for 11h; Green chemistry;

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; pH=1.5; Solvent; Temperature; Reagent/catalyst; Green chemistry;

upstream raw materials:

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

Downstream raw materials:

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate

(S)-(+)-clopidogrel

methyl (S)-2-(2-chlorophenyl)-2-(perfluorophenylsulfonamido)acetate

Refernces

• 1、 -. "Method for preparing 2-thienylethylamine derivatives". . . Retrieved 2008/06/13.