Welcome to LookChem.com Sign In|Join Free

CAS

  • or

40412-06-4

Post Buying Request

40412-06-4 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

40412-06-4 Usage

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Rotigotine

Check Digit Verification of cas no

The CAS Registry Mumber 40412-06-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,4,1 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 40412-06:
(7*4)+(6*0)+(5*4)+(4*1)+(3*2)+(2*0)+(1*6)=64
64 % 10 = 4
So 40412-06-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H14O3S2/c1-11-4-6-13(7-5-11)18(14,15)16-9-8-12-3-2-10-17-12/h2-7,10H,8-9H2,1H3

40412-06-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Thiophen-2-yl)ethyl 4-methylbenzenesulfonate

1.2 Other means of identification

Product number -
Other names 2-(2-thienyl)ethyl toluene-p-sulphonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40412-06-4 SDS

40412-06-4Synthetic route

2-thiophenethanol
5402-55-1

2-thiophenethanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Conditions
ConditionsYield
With triethylamine at 35℃; Cooling with ice;98%
With triethylamine In toluene at 5 - 30℃; for 20.8333h; Product distribution / selectivity;96.37%
With triethylamine In dichloromethane at -5 - 20℃; for 2h;96.5%
2-thiophenethanol
5402-55-1

2-thiophenethanol

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Conditions
ConditionsYield
With triethylamine In di-isopropyl ether at 20℃; for 50h;86%
With ferric nitrate In 1,2-dichloro-ethane Reagent/catalyst; Reflux;78%
water
7732-18-5

water

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Conditions
ConditionsYield
With potassium hydrogensulfate In pyridine
ethyl thiophen-2-ylacetate
57382-97-5

ethyl thiophen-2-ylacetate

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere
2: pyridine / Inert atmosphere
View Scheme
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

α-amino-(2-chlorophenyl)acetic acid methyl ester
141109-16-2

α-amino-(2-chlorophenyl)acetic acid methyl ester

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: 2-(2-thienyl)ethyl tosylate; α-amino-(2-chlorophenyl)acetic acid methyl ester With sodium hydrogencarbonate In acetonitrile at 60 - 70℃; for 48h;
Stage #2: With hydrogenchloride In acetone at -5℃; for 2h; Temperature; Solvent; Reagent/catalyst;
96.61%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

C17H15Cl2NO4

C17H15Cl2NO4

C23H21Cl2NO4S

C23H21Cl2NO4S

Conditions
ConditionsYield
With triethylamine In acetonitrile Reflux;95%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt With sodium carbonate In water at 20℃; Green chemistry;
Stage #2: 2-(2-thienyl)ethyl tosylate With dipotassium hydrogenphosphate In water at 70 - 95℃; for 11h; Green chemistry;
Stage #3: With hydrogenchloride In water; ethyl acetate at 20℃; pH=1.5; Solvent; Temperature; Reagent/catalyst; Green chemistry;
92%
Stage #1: 2-(2-thienyl)ethyl tosylate; (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt With triethylamine at 78 - 82℃; for 8 - 10h;
Stage #2: With hydrogenchloride In isopropyl alcohol Product distribution / selectivity;
42%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Desthienyl-Rotigotine
101470-23-9

Desthienyl-Rotigotine

rotigotine
99755-59-6

rotigotine

Conditions
ConditionsYield
With sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 24h;92%
With sodium sulfite In 5,5-dimethyl-1,3-cyclohexadiene for 48h; Reflux;2.8 kg
With sodium sulfite In 5,5-dimethyl-1,3-cyclohexadiene for 48h; Concentration; Time; Reagent/catalyst; Reflux; Industrial scale;3.06 kg
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate
141109-14-0

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

(S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: 2-(2-thienyl)ethyl tosylate; methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate With sodium hydrogencarbonate; potassium iodide In acetonitrile at 85℃; for 27h;
Stage #2: With hydrogenchloride In water at 20℃; for 2h;
91%
Stage #1: 2-(2-thienyl)ethyl tosylate; methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate With potassium dihydrogen phosphate trihydrate In water at 45 - 100℃; for 15h;
Stage #2: With hydrogenchloride at 0 - 3℃; for 1h; pH=1.2 - 1.5;
89%
Stage #1: 2-(2-thienyl)ethyl tosylate; methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate With dipotassium hydrogenphosphate In acetic acid tert-butyl ester at 92.5℃; for 30h;
Stage #2: With hydrogenchloride In water; ethyl acetate at 12.5℃; for 0.416667h; Product distribution / selectivity;
66.3%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

tert-butylmagnesium chloride
677-22-5

tert-butylmagnesium chloride

2-(3,3-dimethylbutyl)thiophene

2-(3,3-dimethylbutyl)thiophene

Conditions
ConditionsYield
With copper(l) chloride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;87%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

N-(2-(thien-2-yl)ethyl)formamide
28783-49-5

N-(2-(thien-2-yl)ethyl)formamide

Conditions
ConditionsYield
With formic acid at 80℃; for 8.5h; Inert atmosphere;83.5%
tris(2-thienyl)borane

tris(2-thienyl)borane

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

1,2-bis(thiophen-2-yl)ethane
7326-80-9

1,2-bis(thiophen-2-yl)ethane

Conditions
ConditionsYield
Stage #1: tris(2-thienyl)borane; 2-(2-thienyl)ethyl tosylate With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 85℃; Inert atmosphere;
Stage #2: With dihydrogen peroxide; sodium hydroxide In 1,4-dioxane; cyclohexane for 1h; Inert atmosphere;
82.3%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

(S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide

(S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide

rotigotine hydrochloride
125572-93-2

rotigotine hydrochloride

Conditions
ConditionsYield
Stage #1: (S)-1,2,3,4-tetrahydro-5-hydroxy-N-propyl-naphthalen-2-ammonium hydrobromide With sodium carbonate In o-xylene; water at 70 - 80℃;
Stage #2: 2-(2-thienyl)ethyl tosylate With sodium carbonate In o-xylene Reflux;
Stage #3: With hydrogenchloride In o-xylene; water; isopropyl alcohol; toluene at 15 - 55℃;
82%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

4,4,5,5-tetramethyl-2-(2-(thiophen-2-yl)ethyl)-1,3,2-dioxaborolane
1361022-77-6

4,4,5,5-tetramethyl-2-(2-(thiophen-2-yl)ethyl)-1,3,2-dioxaborolane

Conditions
ConditionsYield
With copper(l) iodide; tetra-(n-butyl)ammonium iodide; lithium tert-butoxide In acetonitrile at 60℃; for 18h; Inert atmosphere;74%
With catalyst: CuI/P(C6H5)3 In not given under Ar, base - not given; at 25°C for 18 h;74%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Diphenylphosphine oxide
4559-70-0

Diphenylphosphine oxide

diphenyl(2-(thiophen-2-yl)ethyl)phosphine oxide

diphenyl(2-(thiophen-2-yl)ethyl)phosphine oxide

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; lithium methanolate In 1-methyl-pyrrolidin-2-one at 40℃; for 24h;74%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate
141109-14-0

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate
141109-20-8

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate; potassium iodide In acetonitrile for 12h; Reflux;70%
With triethylamine at 78 - 82℃; for 8 - 10h; Product distribution / selectivity;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

(-)-(S)-5-methoxy-2-[N-2-(2-thienyl)ethylamino]tetralin hydrochloride
1232344-35-2

(-)-(S)-5-methoxy-2-[N-2-(2-thienyl)ethylamino]tetralin hydrochloride

Conditions
ConditionsYield
Stage #1: 2-(2-thienyl)ethyl tosylate; (S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride With potassium carbonate In acetonitrile at 20 - 85℃;
Stage #2: With hydrogenchloride In water; ethyl acetate at 0 - 85℃;
70%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

(S)-(+)-clopidogrel
113665-84-2

(S)-(+)-clopidogrel

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 8.5h; Product distribution / selectivity; Heating / reflux;58%
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

1‐(2‐chloroethyl)‐4,5‐dihydro‐1H‐1,2,3,4‐tetrazol‐5‐one
56413-06-0

1‐(2‐chloroethyl)‐4,5‐dihydro‐1H‐1,2,3,4‐tetrazol‐5‐one

1-(2-chloroethyl)-1,4-dihydro-4-<2-(2-thienyl)ethyl>-5H-tetrazol-5-one
69049-05-4

1-(2-chloroethyl)-1,4-dihydro-4-<2-(2-thienyl)ethyl>-5H-tetrazol-5-one

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 70℃;46.5%
(-)-5-hydroxy-N-(n-propyl)-2-aminotetralin

(-)-5-hydroxy-N-(n-propyl)-2-aminotetralin

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(-)-5-hydroxy-N-(n-propyl)-2-aminotetralin toluenesulfonate

(-)-5-hydroxy-N-(n-propyl)-2-aminotetralin toluenesulfonate

B

((S)-6-(propyl(2-thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol heminaphthalene-1,5-disulfonate

((S)-6-(propyl(2-thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol heminaphthalene-1,5-disulfonate

Conditions
ConditionsYield
Stage #1: (-)-5-hydroxy-N-(n-propyl)-2-aminotetralin; 2-(2-thienyl)ethyl tosylate In iso-butylacetate at 110℃; for 10h;
Stage #2: naphthalene-1,5-disulfonate In isopropyl alcohol; acetone at 20℃; Product distribution / selectivity;
A n/a
B 37.8%
Stage #1: (-)-5-hydroxy-N-(n-propyl)-2-aminotetralin; 2-(2-thienyl)ethyl tosylate In 2-methylpropyl acetate at 110℃; for 10h;
Stage #2: naphthalene-1,5-disulfonate In isopropyl alcohol; acetone at 20℃;
Stage #1: (-)-5-hydroxy-N-(n-propyl)-2-aminotetralin; 2-(2-thienyl)ethyl tosylate In iso-butylacetate at 110℃; for 10h;
Stage #2: naphthalene-1,5-disulfonate In isopropyl alcohol; acetone at 20℃;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

N-((fluoromethyl)(oxo)(phenyl)-λ6-sulfaneylidene)-4-methylbenzenesulfonamide
1097193-08-2

N-((fluoromethyl)(oxo)(phenyl)-λ6-sulfaneylidene)-4-methylbenzenesulfonamide

N-((1-fluoro-3-(thiophen-2-yl)propyl)(oxo)(phenyl)-λ6-sulfaneylidene)-4-methylbenzenesulfonamide

N-((1-fluoro-3-(thiophen-2-yl)propyl)(oxo)(phenyl)-λ6-sulfaneylidene)-4-methylbenzenesulfonamide

Conditions
ConditionsYield
Stage #1: N-((fluoromethyl)(oxo)(phenyl)-λ6-sulfaneylidene)-4-methylbenzenesulfonamide With tert.-butyl lithium In tetrahydrofuran; hexane at -78℃; for 1h; Schlenk technique; Inert atmosphere;
Stage #2: 2-(2-thienyl)ethyl tosylate In tetrahydrofuran; hexane at -78 - 20℃; for 24h; Schlenk technique; Inert atmosphere;
27%
piperidine
110-89-4

piperidine

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

1-<2-(2-Thienyl)ethyl>piperidine Hydrochloride
122861-43-2

1-<2-(2-Thienyl)ethyl>piperidine Hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium carbonate 1) toluene, reflux, 3,5 h, 2) diethyl ether;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

ethyl thioglycolate sodium salt
55163-91-2

ethyl thioglycolate sodium salt

(2-Thiophen-2-yl-ethylsulfanyl)-acetic acid ethyl ester
107291-81-6

(2-Thiophen-2-yl-ethylsulfanyl)-acetic acid ethyl ester

Conditions
ConditionsYield
In ethanol for 1h; Yield given;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

1-(phenylmethyl)-N-(4-piperidinyl)-1H-benzimidazol-2-amine
75970-76-2

1-(phenylmethyl)-N-(4-piperidinyl)-1H-benzimidazol-2-amine

1-(phenylmethyl)-N-<1-<2-(2-thienyl)ethyl>-4-piperidinyl>-1H-benzimidazol-2-amine
98244-82-7

1-(phenylmethyl)-N-<1-<2-(2-thienyl)ethyl>-4-piperidinyl>-1H-benzimidazol-2-amine

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 70℃;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Norfentanyl
1609-66-1

Norfentanyl

N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride
79278-88-9

N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; sodium carbonate 1) toluene, reflux, 3,5 h, 2) diethyl ether; Multistep reaction;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

4-(cyclohexylcarbonyl)-2,6-dioxopiperazine
87693-73-0

4-(cyclohexylcarbonyl)-2,6-dioxopiperazine

4-cyclohexylcarbonyl-N-<2-(2-thienyl)ethyl>piperazine-2,6-dione
89508-14-5

4-cyclohexylcarbonyl-N-<2-(2-thienyl)ethyl>piperazine-2,6-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 85℃; for 2h;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt
213018-92-9

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate
141109-20-8

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate

Conditions
ConditionsYield
With triethylamine at 78 - 82℃; for 8 - 10h; Product distribution / selectivity;
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

1-{2-[5-oxo-4-(2-thiophen-2-yl-ethyl)-4,5-dihydro-tetrazol-1-yl]-ethyl}-4-(N-propionyl-anilino)-piperidine-4-carboxylic acid methyl ester
69049-11-2

1-{2-[5-oxo-4-(2-thiophen-2-yl-ethyl)-4,5-dihydro-tetrazol-1-yl]-ethyl}-4-(N-propionyl-anilino)-piperidine-4-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 46.5 percent / Na2CO3 / dimethylformamide / 70 °C
2: Na2CO3 / dimethylformamide / 70 °C
View Scheme
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

6,7-Dihydro-4H-thieno[3,2-c]thiopyran-4-carboxylic acid
107292-02-4

6,7-Dihydro-4H-thieno[3,2-c]thiopyran-4-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethanol / 1 h
2: N-chlorosuccinimide / CCl4 / Ambient temperature; overnight
3: 62 percent / SnCl4 / CH2Cl2
4: 92 percent / aq. 6N NaOH / 0.5 h / Heating
View Scheme
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

6,7-Dihydro-4H-thieno[3,2-c]thiopyran-4-carboxylic acid ethyl ester
107291-97-4

6,7-Dihydro-4H-thieno[3,2-c]thiopyran-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 1 h
2: N-chlorosuccinimide / CCl4 / Ambient temperature; overnight
3: 62 percent / SnCl4 / CH2Cl2
View Scheme
2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Chloro-(2-thiophen-2-yl-ethylsulfanyl)-acetic acid ethyl ester
107291-89-4

Chloro-(2-thiophen-2-yl-ethylsulfanyl)-acetic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 1 h
2: N-chlorosuccinimide / CCl4 / Ambient temperature; overnight
View Scheme

40412-06-4Relevant articles and documents

Preparation method of clopidogrel hydrogen sulfate intermediate

-

Paragraph 0032, (2021/05/15)

The present invention relates to a preparation method of a clopidogrel hydrogen sulfate intermediate. (+)-2-chlorophenylglycine methyl ester and alpha-thiopheneethanol p-toluenesulfonate are adopted as raw materials, a reaction solvent and an acid-binding agent are added for a condensation reaction, the condensation reaction process is divided into a first stage and a second stage, and when 60-95% of the condensation reaction is completed, first-stage reaction is completed; after the first-stage reaction is completed, firstly part of the reaction solvent is removed, and then second-stage reaction is carried out; and after the second-stage reaction is completed, a target product is obtained, namely the clopidogrel hydrogen sulfate intermediate. After the first-stage reaction is completed, part of the reaction solvent is removed firstly, and then the second-stage reaction is continued, so that the concentration of the reaction material can be increased in the later stage of the condensation reaction, the use amount of the reaction solvent is reduced, and racemization and side reaction in the reaction process are effectively inhibited, thereby improving the chiral purity of the product, increasing the yield, reducing the use of auxiliary materials greatly, and reducing the production cost.

Structure-Odor Correlations in Homologous Series of Mercapto Furans and Mercapto Thiophenes Synthesized by Changing the Structural Motifs of the Key Coffee Odorant Furan-2-ylmethanethiol

Schoenauer, Sebastian,Schieberle, Peter

, p. 4189 - 4199 (2018/05/01)

Furan-2-ylmethanethiol (2-furfurylthiol; 2-FFT, 1) is long-known as a key odorant in roast and ground coffee and was also previously identified in a wide range of thermally treated foods such as meat, bread, and roasted sesame seeds. Its unique coffee-like odor quality elicited at very low concentrations, and the fact that only a very few compounds showing a similar structure have previously been described in foods make 1 a suitable candidate for structure-odor activity studies. To gain insight into the structural features needed to evoke a coffee-like odor at low concentrations, 46 heterocyclic mercaptans and thio ethers were synthesized, 32 of them for the first time, and their odor qualities and odor thresholds were determined. A movement of the mercapto group to the 3-position kept the coffee-like aroma but led to an increase in odor threshold. A separation of the thiol group from the furan ring by an elongation of the carbon side chain caused a loss of the coffee-like odor and also led to an increase in odor thresholds, especially for ω-(furan-2-yl)alkane-1-thiols with six or seven carbon atoms in the side chain. A displacement of the furan ring by a thiophene ring had no significant influence on the odor properties of most of the compounds studied, but the newly synthesized longer-chain 1-(furan-2-yl)- and 1-(thiophene-2-yl)alkane-1-thiols elicited interesting passion fruit-like scents. In total, only 4 out of the 46 compounds also showed a coffee-like odor quality like 1, but none showed a lower odor threshold. Besides the odor attributes, also retention indices, mass spectra, and NMR data of the synthesized compounds were elaborated, which are helpful in possible future identification of these compounds in trace levels in foods or other materials.

Method for preparing D-(+)-alpha-(2-thiopheneethylamino)-alpha-(2-chlorophenyl)methyl acetate hydrochloride

-

Paragraph 0009; 0058; 0064; 0067; 0076; 0083; 0094; 0103, (2018/12/14)

The invention provides a novel method for preparing D-(+)-alpha-(2-thiopheneethylamino)-alpha-(2-chlorophenyl)methyl acetate hydrochloride, aiming at solving the technical problems of a traditional synthesis technology of the D-(+)-alpha-(2-thiopheneethylamino)-alpha-(2-chlorophenyl)methyl acetate hydrochloride that the technology is complicated, the cost is high and the yield is low. The method comprises the following steps: 1) preparing 2-bromothiophene; 2) preparing 2-thiopheneethanol; 3) preparing 2-thiopheneethanol p-toluenesulfonate; 4) preparing L-(+)-o-chlorophenylglycine methyl esterL-tartrate; 5) preparing the D-(+)-alpha-(2-thiopheneethylamino)-alpha-(2-chlorophenyl)methyl acetate hydrochloride. The preparation method provided by the invention is low in cost, high in yield andhigh in safety and is suitable for industrial production.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 40412-06-4