2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid

Base Information

Chemical Name:2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid
CAS No.:1354924-86-9
Molecular Formula:C₃₀H₃₆N₃O₉PS
Molecular Weight:645.67
Hs Code.:

Synonyms:2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid

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Chemical Property of 2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid

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Technology Process of 2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid

There total 8 articles about 2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1354924-81-4
2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

: 1354924-86-9
2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm2013826

Reference yield:

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 1354924-86-9
2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / 1,4-dioxane; water / 1 h / 20 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 21 h / 0 - 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / ethanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 16 h / 20 °C

5.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 1 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; tributylphosphine; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2013826

Reference yield:

: 1354924-79-0
methyl 4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethyloxy]benzoate

: 1354924-86-9
2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / ethanol / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 16 h / 20 °C

3.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 1 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2013826