2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

Base Information

Chemical Name:2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid
CAS No.:1354924-81-4
Molecular Formula:C₃₀H₃₆N₃O₈PS
Molecular Weight:629.671
Hs Code.:

Synonyms:2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

Suppliers and Price of 2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

There total 6 articles about 2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1354924-74-5
2-amino-1-(phenylsulfonamido)ethylphosphinic acid

: 1354924-80-3
4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethyloxy]benzoic acid

: 1354924-81-4
2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

Guidance literature:: 4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethyloxy]benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

2-amino-1-(phenylsulfonamido)ethylphosphinic acid; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm2013826

Reference yield:

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 1354924-81-4
2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / 1,4-dioxane; water / 1 h / 20 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 21 h / 0 - 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / ethanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 16 h / 20 °C

With tributylphosphine; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2013826

Reference yield:

: 1354924-79-0
methyl 4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethyloxy]benzoate

: 1354924-81-4
2-{4-[2-(N-(benzyloxycarbonyl)piperidin-4-yl)ethoxy]benzamido}-1-(phenylsulfonamido)ethylphosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / ethanol / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 16 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2013826