3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

Base Information

Chemical Name:3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester
CAS No.:1227259-20-2
Molecular Formula:C₁₇H₂₁FO₄
Molecular Weight:308.35
Hs Code.:

Synonyms:3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

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Chemical Property of 3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

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Technology Process of 3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

There total 4 articles about 3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227259-18-8
2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

: 1227259-20-2
3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

Guidance literature:: 2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester; With water; lithium hydroxide; In ethanol; at 20 ℃; Reflux;

With hydrogenchloride; In water; at 10 ℃; pH=2.75;

Reference yield:

: 1227259-18-8
2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

: 1227259-20-2
3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

: C₁₃H₁₃FO₄

Guidance literature:: With lithium hydroxide; In ethanol; water; at 18 - 82 ℃; for 76.5h; Reagent/catalyst; Large scale;
DOI:10.1021/op300306c

Reference yield:

: 32864-38-3
tert-Butyl ethyl malonate

: 1227259-20-2
3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate / N,N-dimethyl-formamide / 1 h / 20 °C / Large scale

1.2: 2.83 h / 20 °C / Large scale

2.1: lithium hydroxide / ethanol; water / 76.5 h / 18 - 82 °C / Large scale

With lithium hydroxide; sodium t-butanolate; In ethanol; water; N,N-dimethyl-formamide; 1.1: |Michael Addition / 1.2: |Michael Addition;
DOI:10.1021/op300306c