2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

Base Information

Chemical Name:2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester
CAS No.:1227259-18-8
Molecular Formula:C₂₂H₂₉FO₆
Molecular Weight:408.467
Hs Code.:

Synonyms:2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

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Chemical Property of 2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

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Technology Process of 2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

There total 1 articles about 2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32864-38-3
tert-Butyl ethyl malonate

: 189626-04-8
4-(4-fluorophenyl)-2-methylbuta-2,3-dienoic acid ethyl ester

: 1227259-18-8
2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

Guidance literature:: tert-Butyl ethyl malonate; With potassium tert-butylate; In N,N-dimethyl acetamide; at 25 ℃;

4-(4-fluorophenyl)-2-methylbuta-2,3-dienoic acid ethyl ester; In N,N-dimethyl acetamide; at 20 - 28 ℃;

Reference yield:

: 1227259-18-8
2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

: 1227259-20-2
3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

Guidance literature:: 2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester; With water; lithium hydroxide; In ethanol; at 20 ℃; Reflux;

With hydrogenchloride; In water; at 10 ℃; pH=2.75;

Reference yield:

: 1227259-18-8
2-ethoxycarbonyl-3-[1-(4-fluorophenyl)meth-(E)-ylidene]-4-methylpentanedioic acid 1-tert-butyl ester 5-ethyl ester

: 1227259-20-2
3-[1-(4-fluorophenyl)meth-(Z)-ylidene]-2-methylpentanedioic acid 5-tert-butyl ester

: C₁₃H₁₃FO₄

Guidance literature:: With lithium hydroxide; In ethanol; water; at 18 - 82 ℃; for 76.5h; Reagent/catalyst; Large scale;
DOI:10.1021/op300306c