((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester
CAS No.:477332-15-3
Molecular Formula:C₁₈H₂₉NO₄
Molecular Weight:323.433
Hs Code.:

Synonyms:((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

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Chemical Property of ((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

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Technology Process of ((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

There total 1 articles about ((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 477332-07-3
((1R,2S)-1-Benzyloxymethyl-2-methyl-but-3-enyl)-carbamic acid tert-butyl ester

: 477332-15-3
((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide;
DOI:10.1016/S0040-4039(02)01553-8

Reference yield: 98.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 477332-15-3
((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

: 477332-08-4
[1-benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-carbamic acid tert-butyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01553-8

Reference yield:

: 477332-15-3
((1R,2S)-1-Benzyloxymethyl-4-hydroxy-2-methyl-butyl)-carbamic acid tert-butyl ester

: 3-(tert-butyl-diphenyl-silanyloxy)-9-(2''-methoxymethoxymethyl-[2,4';2',4'']teroxazol-4-yl)-7-oxo-decanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: 98 percent / imidazole / dimethylformamide

2.1: 82 percent / BCl₃ / toluene

3.1: 94 percent / DCC; DMAP / CH₂Cl₂

4.1: TFA / CH₂Cl₂

5.1: 68 percent / DCC; HOBT / dimethylformamide

6.1: 100 percent / K₂CO₃; MeOH

7.1: Dess-Martin periodinane

8.1: dibromotetrachloroethane; triphenylphosphine; 2,6-lutidine

8.2: 90 percent / DBU / acetonitrile

9.1: 92 percent / TBAF; AcOH / CH₂Cl₂

10.1: 98 percent / Dess-Martin periodinane

11.1: 78 percent / CrCl₂; NiCl₂ / tetrahydrofuran; dimethylsulfoxide

12.1: 99 percent / Dess-Martin periodinane

13.1: 100 percent / PPh₃; TBAF; PhMe₂SiH / CuCl

With 1H-imidazole; 2,6-dimethylpyridine; chromium dichloride; methanol; dmap; dibromotetrachloroethane; Dimethylphenylsilane; tetrabutyl ammonium fluoride; boron trichloride; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; nickel dichloride; copper(l) chloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 11.1: Kishi-Nozaki coupling;
DOI:10.1016/S0040-4039(02)01553-8