2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

Base Information

Chemical Name:2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide
CAS No.:1027898-58-3
Molecular Formula:C₂₄H₂₀N₂O₄
Molecular Weight:400.434
Hs Code.:

Synonyms:2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

Chemical Property:

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Technology Process of 2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

There total 11 articles about 2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182116-34-3
2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

: 1027898-58-3
2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm960395q

Reference yield:

: 211299-41-1
o-(iodomethyl)biphenyl

: 1027898-58-3
2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 2 h / Ambient temperature

2: tetrahydrofuran / 1 h / 0 °C

3: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

4: H₂ / 10percent Pd/C / ethyl acetate

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 2584-12-5
ethyl 3-hydroxy-2-pyridineacetate

: 1027898-58-3
2-(3-Biphenyl-2-ylmethyl-8-hydroxy-2-methoxy-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) 60percent NaH / 1.) DMF, 0 deg C, 50 min, 2.) DMF, overnight

2: 18 h / 50 °C

3: K₂CO₃ / butan-2-one / 4 h / Ambient temperature

4: K₂CO₃ / butan-2-one / 60 °C

5: aq. KOH / dimethylsulfoxide

6: toluene / 1 h / Heating

7: benzene / 2 h / Ambient temperature

8: tetrahydrofuran / 1 h / 0 °C

9: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

10: H₂ / 10percent Pd/C / ethyl acetate

With potassium hydroxide; ammonium hydroxide; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; toluene; butanone; benzene;
DOI:10.1021/jm960395q