3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide

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Chemical Name:3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide
CAS No.:1282606-51-2
Molecular Formula:C₂₀H₁₉FN₆O₂
Molecular Weight:394.408
Hs Code.:

Synonyms:3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide

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Chemical Property of 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide

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Technology Process of 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide

There total 4 articles about 3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₇FN₆O₃

: 1282606-51-2
3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide

Guidance literature:: C₂₈H₂₇FN₆O₃; With trifluorormethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; at 0 ℃;

Reference yield:

: 1282606-67-0
methyl 3-(3-(2-chloroethyl)ureido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

: 1282606-51-2
3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

2.1: caesium carbonate / acetone / 32 h / Reflux

3.1: sodium hydroxide / ethanol / 1 h / Reflux

3.2: pH 1 - 2

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 72 h / 20 °C

5.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 2 h / 20 °C

5.2: 0 °C

With trifluorormethanesulfonic acid; sodium hydride; benzotriazol-1-ol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 1282606-66-9
methyl 1-(4-methoxybenzyl)-3-(2-oxoimidazolidin-1-yl)-1H-pyrazole-5-carboxylate

: 1282606-51-2
3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-1Hpyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetone / 32 h / Reflux

2.1: sodium hydroxide / ethanol / 1 h / Reflux

2.2: pH 1 - 2

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 72 h / 20 °C

4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 2 h / 20 °C

4.2: 0 °C

With trifluorormethanesulfonic acid; benzotriazol-1-ol; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetone;