N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide

Base Information

Chemical Name:N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide
CAS No.:101345-72-6
Molecular Formula:C₂₂H₂₉FN₂O₂S
Molecular Weight:404.549
Hs Code.:

Synonyms:N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide

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Chemical Property of N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide

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Technology Process of N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide

There total 10 articles about N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 101345-72-6
1-[2-(2-thienyl)ethyl]-3-methyl-4-[N-(2-fluorophenyl)-2-methoxypropionamido]piperidine

Guidance literature:

Reference yield:

: 348-54-9
2-Fluoroaniline

: 101345-72-6
N-(2-Fluoro-phenyl)-2-methoxy-N-[(3R,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonic acid / toluene / Heating

2: NaBH₄ / methanol / Ambient temperature

3: CH₂Cl₂

4: H₂ / 10percent Pd(OH)2/C / ethanol / 2585.7 Torr

5: Na₂CO₃, NaI / acetonitrile

With sodium tetrahydroborate; hydrogen; sodium carbonate; toluene-4-sulfonic acid; sodium iodide; palladium dihydroxide; In methanol; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm00172a032

Reference yield:

: 34737-89-8
1-Benzyl-3-methyl-4-piperidon

: 101345-72-6
N-(2-Fluoro-phenyl)-2-methoxy-N-[(3R,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonic acid / toluene / Heating

2: NaBH₄ / methanol / Ambient temperature

3: CH₂Cl₂

4: H₂ / 10percent Pd(OH)2/C / ethanol / 2585.7 Torr

5: Na₂CO₃, NaI / acetonitrile

With sodium tetrahydroborate; hydrogen; sodium carbonate; toluene-4-sulfonic acid; sodium iodide; palladium dihydroxide; In methanol; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm00172a032