4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene

Base Information

Chemical Name:4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene
CAS No.:171011-39-5
Molecular Formula:C₁₄H₂₃BrO₂Si
Molecular Weight:331.325
Hs Code.:

Synonyms:4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene

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Technology Process of 4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene

There total 2 articles about 4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 171011-37-3
4-bromo-2-(hydroxymethyl)benzyl alcohol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 171011-39-5
4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene

Guidance literature:: With dmap; In tetrahydrofuran; N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1021/jm00022a019

Reference yield:

: 87639-57-4
4-bromophthalic Acid Dimethyl Ester

: 171011-39-5
4-<<(tert-butyldimethylsilyl)oxy>methyl>-3-(hydroxymethyl)-1-bromobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / a) RT, 1 h, b) reflux, 1.5 h

2: 37 percent / 4-(dimethylamino)pyridine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a019