3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline

Base Information

Chemical Name:3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline
CAS No.:177478-62-5
Molecular Formula:C₂₉H₃₂Cl₂N₆O₅
Molecular Weight:615.516
Hs Code.:

Synonyms:3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline

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Chemical Property of 3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline

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Technology Process of 3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline

There total 5 articles about 3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177478-30-7
2-amino-3-[(2-methoxyethyl)amino]phenol

: 194928-59-1
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

: 177478-62-5
3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline

Guidance literature:: 2-amino-3-[(2-methoxyethyl)amino]phenol; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm030468n

Reference yield:

: 177477-63-3
tert-butyl 3-(benzyloxy)-2-nitrophenylcarbamate

: 177478-62-5
3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77.7 percent / K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 6 h / 100 °C

2.1: 97.3 percent / HCl / ethyl acetate / 1 h / 20 °C

3.1: 99.9 percent / H₂ / Pd/C / ethanol; dioxane / 20 °C

4.1: NaH / dimethylformamide / 0.5 h

4.2: dimethylformamide / 1 h / 20 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n

Reference yield:

: 177478-12-5
3-(benzyloxy)-N-(2-methoxyethyl)-2-nitroaniline

: 177478-62-5
3-[3-[N-[(E)-3-(6-acetamidopyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-amino-N-(2-methoxyethyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99.9 percent / H₂ / Pd/C / ethanol; dioxane / 20 °C

2.1: NaH / dimethylformamide / 0.5 h

2.2: dimethylformamide / 1 h / 20 °C

With hydrogen; sodium hydride; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n