(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

Base Information

Chemical Name:(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide
CAS No.:194928-59-1
Molecular Formula:C₂₀H₁₉Cl₃N₄O₃
Molecular Weight:469.755
Hs Code.:

Synonyms:(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

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Technology Process of (2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

There total 2 articles about (2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

: 177478-45-4
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[2,4-dichloro-3-(hydroxymethyl)methylanilino]-2-oxoethyl}-2-propenamide

: 194928-59-1
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

Guidance literature:: With methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm030468n

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 177478-45-4
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[2,4-dichloro-3-(hydroxymethyl)methylanilino]-2-oxoethyl}-2-propenamide

: 194928-59-1
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

: 177478-44-3
3-[N-[(E)-3-(6-Acetamidopyridin-3-yl)acryloylglycyl)-N-methylamino]-1-[tert-butyldiphenylsilyloxymethyl]-2,6-dichlorobenzene

Guidance literature:: With sodium bicarbonate; triethylamine; In N,N-dimethyl-formamide;

Reference yield: 66.6%

: 59649-56-8
2,3-diaminophenol

: 194928-59-1
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide

: 177478-41-0
(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[2,4-dichloro-3-[(2,3-diaminophenoxy)methyl]methylanilino]-2-oxoethyl}-2-propenamide

Guidance literature:: 2,3-diaminophenol; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h; cooling;

(2E)-3-[6-(acetylamino)-3-pyridinyl]-N-{2-[3-(chloromethyl)-2,4-dichloromethylanilino]-2-oxoethyl}-2-propenamide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.5h;
DOI:10.1021/jm030468n