3,4-Dichlorophenylmagnesium bromide

Base Information

• Chemical Name: 3,4-Dichlorophenylmagnesium bromide
• CAS No.: 79175-35-2
• Molecular Formula: C6H3BrCl2Mg
• Molecular Weight: 250.205
• Hs Code.: 29310099
• European Community (EC) Number: 696-163-6
• Mol file: 79175-35-2.mol

Synonyms:3,4-DICHLOROPHENYLMAGNESIUM BROMIDE;79175-35-2;MFCD01319891;3,4-Dichlorophenylmagnesium bromide, 0.50 M in 2-MeTHF;SCHEMBL155088;3,4-Dichlorphenylmagnesiumbromid;IRROSODEQHIZEV-UHFFFAOYSA-M;bromo(3,4-dichlorophenyl)magnesium;3,4-dichlorophenyl magnesium bromide;3,4-dichlorophenyl-magnesium bromide;(3,4-dichlorophenyl)magnesium bromide;AKOS015916235;3,4-Dichlorophenylmagnesium bromide, 0.5M THF;3,4-Dichlorophenylmagnesium bromide, 0.50 M in THF;3,4-Dichlorophenylmagnesium bromide, 0.50M in 2-MeTHF;3,4-Dichlorophenylmagnesium bromide 0.5 M in Tetrahydrofuran

Chemical Property of 3,4-Dichlorophenylmagnesium bromide

Chemical Property:

• Vapor Pressure: 1.21mmHg at 25°C
• Boiling Point: 180.5°C at 760 mmHg
• Flash Point: 1 °F
• PSA: 0.00000
• Density: 0.980 g/mL at 25 °C
• LogP: 3.63920
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 247.86456
• Heavy Atom Count: 10
• Complexity: 184

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4-Dichlorophenylmagnesium bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C,Xn
• Statements: 11-14-19-22-34-40-36/37
• Safety Statements: 16-26-33-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=[C-]1)Cl)Cl.[Mg+2].[Br-]

Technology Process of 3,4-Dichlorophenylmagnesium bromide

There total 2 articles about 3,4-Dichlorophenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromo-1,2-dichlorobenzene (18282-59-2) → 3,4-dichlorophenylmagnesium bromide (79175-35-2)

Guidance literature:

With magnesium; In tetrahydrofuran; at 20 - 25 ℃; for 5h;

Reference yield:

4-bromo-1,2-dichlorobenzene (18282-59-2) + magnesium (7439-95-4) → 3,4-dichlorophenylmagnesium bromide (79175-35-2)

Guidance literature:

4-bromo-1,2-dichlorobenzene; magnesium; With iodine; In tetrahydrofuran; dibromoethane, 1,2-; for 0.75h; Heating / reflux;

With copper(l) iodide; In tetrahydrofuran; dibromoethane, 1,2-; dimethylsulfide; at -30 ℃; for 2h;

Reference yield: 98.0%

2-furancarbonitrile (617-90-3) + 3,4-dichlorophenylmagnesium bromide (79175-35-2) → (3,4-dichlorophenyl)(furan-2-yl)methanimine

Guidance literature:

In toluene; at -78 - 20 ℃; for 12h;

upstream raw materials:

4-bromo-1,2-dichlorobenzene

magnesium

Downstream raw materials:

(1S,2S)-1-(3,4-Dichloro-phenyl)-2-imidazol-1-yl-cyclohexanol

(1S,2R)-1-(3,4-Dichloro-phenyl)-2-imidazol-1-yl-cyclohexanol

(1S,2S)-1-(3,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-yl-cycloheptanol

3-(3-Chloro-phenyl)-2-cyano-3-(3,4-dichloro-phenyl)-propionic acid methyl ester

Refernces

• 1、 -. "A method for preparing substituted biphenyl". Paragraph 0129; 0131; 0132. . Retrieved 2018/08/03.
• 2、 -. "Piperdine derivatives useful as CCR3 antagonists". Page/Page column 36. . Retrieved 2008/06/13.