2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone

Base Information

• Chemical Name: 2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone
• CAS No.: 380196-84-9
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.798

Synonyms:2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone

Chemical Property of 2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone

There total 6 articles about 2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

chloroacetic acid (79-11-8) + 5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole (76973-46-1) → 2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone (380196-84-9)

Guidance literature:

at 110 ℃; for 1h;

DOI:10.1080/00397911.2015.1104357

Reference yield: 73.0%

chloroacetyl chloride (79-04-9) + 5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole (76973-46-1) → 2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone (380196-84-9)

Guidance literature:

With triethylamine; In benzene; at 20 ℃; for 1h;

DOI:10.1080/104265090930452

Reference yield: 68.0%

chloroacetyl chloride (79-04-9) + 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one (959-33-1) → 2-chloro-1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethenone (380196-84-9)

Guidance literature:

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one; With hydrazine hydrate; In chloroform; at 80 ℃; for 12h;

chloroacetyl chloride; With potassium carbonate; In chloroform; at 20 ℃; for 12h;

DOI:10.1016/j.bioorg.2020.104527

upstream raw materials:

chloroacetyl chloride

5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

chloroacetic acid

Downstream raw materials:

1-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-1H-indole-2,3-dione

5-(1-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

5-(1-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-thioxo-4-thiazolidinone

C₂₅H₂₂N₄O₂S

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