2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

Base Information

Chemical Name:2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone
CAS No.:1374242-70-2
Molecular Formula:C₁₄H₁₉Cl₂N₃O
Molecular Weight:316.23
Hs Code.:

Synonyms:2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

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Chemical Property of 2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

Chemical Property:

Purity/Quality:

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Technology Process of 2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

There total 6 articles about 2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374242-69-9
tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

: 1374242-70-2
2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield:

: 216854-23-8,172603-05-3
tert-butyl (S)-piperidin-3-yl-carbamate

: 1374242-70-2
2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 0 °C

2.2: 4 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; paraffin oil (nujol); dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 876379-22-5
benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

: 1374242-70-2
2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 0 °C

1.2: 4 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; paraffin oil (nujol); N,N-dimethyl-formamide;