tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

Base Information

Chemical Name:tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate
CAS No.:1374242-69-9
Molecular Formula:C₁₉H₂₇Cl₂N₃O₃
Molecular Weight:416.348
Hs Code.:

Synonyms:tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

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Chemical Property of tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

There total 4 articles about tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 309962-63-8
methyl-(S)-piperidin-3-yl-carbamic acid tert-butyl ester

: 42288-29-9
2-((3,5-dichlorophenyl)arnino)acetic acid

: 1374242-69-9
tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 216854-23-8,172603-05-3
tert-butyl (S)-piperidin-3-yl-carbamate

: 1374242-69-9
tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 0 °C

2.2: 4 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; paraffin oil (nujol); dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 876379-22-5
benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

: 1374242-69-9
tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 0 °C

1.2: 4 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; paraffin oil (nujol); N,N-dimethyl-formamide;