N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

Base Information

Chemical Name:N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide
CAS No.:1434081-78-3
Molecular Formula:C₃₂H₃₇N₃O₁₀S
Molecular Weight:655.726
Hs Code.:

N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

Synonyms:N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

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Chemical Property of N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

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Technology Process of N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

There total 3 articles about N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63758-12-3
6-chlorosulfonyl-1,4-benzodioxane

: 1434081-81-8
C₂₄H₃₁N₃O₆

: 1434081-78-3
N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/jm400397x

Reference yield:

: 1314311-47-1
tert-butyl ((((2R,3R)-5-(S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

: 1434081-78-3
N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 1 h / 20 °C

2: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

3: 2,6-dimethylpyridine / dichloromethane / 20 h / 20 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm400397x

Reference yield:

: 1434081-80-7
C₃₁H₄₅N₃O₈Si

: 1434081-78-3
N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

2: 2,6-dimethylpyridine / dichloromethane / 20 h / 20 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm400397x