1434081-80-7

Basic information

• Product Name: C₃₁H₄₅N₃O₈Si
• CAS NO: 1434081-80-7
• Molecular Weight: 615.799
• Mol File: 1434081-80-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₄₅N₃O₈Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₄₅N₃O₈Si(1434081-80-7)
• EPA Substance Registry System: C₃₁H₄₅N₃O₈Si(1434081-80-7)

Safety Data

• Hazardous Substances Data: 1434081-80-7(Hazardous Substances Data)

Upstream product

• 1027156-11-1 tert-butyldimethylsilyl 2-methylpropane-2-sulfonate 
• 1314311-47-1 tert-butyl ((((2R,3R)-5-(S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate 

Downstream Products

• 1434081-81-8 C₂₄H₃₁N₃O₆ 
• 1434081-78-3 N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide 
• 1434081-79-4 N-(((2R,3R)-10-amino-5-((S)-1-((4-methoxybenzyl)oxy)-propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b]-[1,5]oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b]-[1,4]dioxine-6-sulfonamide 
• 1434081-77-2 C₃₃H₃₇N₃O₉S 
• 1434081-67-0 C₄₃H₄₆N₄O₉S 
• 1434081-68-1 C₄₄H₄₈N₄O₉S 
• 1434081-69-2 C₄₄H₄₈N₄O₉S 
• 1434081-70-5 C₄₂H₄₅N₅O₉S 
• 1434081-71-6 C₄₂H₄₅N₅O₉S 
• 1434081-72-7 C₄₂H₄₅N₅O₉S 
• 1434081-73-8 C₄₂H₄₅N₅O₉S 
• 1434081-74-9 C₄₂H₄₅N₅O₉S 
• 1434081-75-0 C₄₂H₄₅N₅O₉S 
• 1434081-76-1 C₄₂H₄₅N₅O₉S 

Relevant articles and documents

Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility

We previously reported the discovery of BRD0476 (1), a small molecule generated by diversity-oriented synthesis that suppresses cytokine-induced β-cell apoptosis. Herein, we report the synthesis and biological evaluation of 1 and analogues with improved aqueous solubility. By replacing naphthyl with quinoline moieties, we prepared active analogues with up to a 1400-fold increase in solubility from 1. In addition, we demonstrated that 1 and analogues inhibit STAT1 signal transduction induced by IFN-γ.