N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide

Base Information

Chemical Name:N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide
CAS No.:1351940-53-8
Molecular Formula:C₂₉H₂₄ClN₅O₄
Molecular Weight:541.994
Hs Code.:

Synonyms:N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide

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Chemical Property of N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide

Chemical Property:

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Technology Process of N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide

There total 13 articles about N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351943-50-4
6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 814-68-6,25189-84-8
acryloyl chloride

: 1351940-53-8
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide

Guidance literature:: With pyridine; dmap; In tetrahydrofuran; at 0 - 20 ℃; for 5.5h;

Reference yield:

: 1351942-45-4
4-hydroxy-6-nitro-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351940-53-8
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

2: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

3: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

4: dmap; pyridine / tetrahydrofuran / 5.5 h / 0 - 20 °C

With pyridine; dmap; tin(II) chloride dihdyrate; pyridine hydrochloride; trichlorophosphate; In tetrahydrofuran; ethanol; isopropyl alcohol;

Reference yield:

: 1351942-44-3
(E/Z)-ethyl 2-cyano-3-(4-nitro-3-(tetrahydrofuran-3-yl-oxy)-phenylamino)-acrylate

: 1351940-53-8
N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: biphenyl; diphenylether / 2 h / 256 °C / Inert atmosphere

2: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

3: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

4: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

5: dmap; pyridine / tetrahydrofuran / 5.5 h / 0 - 20 °C

With pyridine; dmap; tin(II) chloride dihdyrate; pyridine hydrochloride; trichlorophosphate; In tetrahydrofuran; diphenylether; biphenyl; ethanol; isopropyl alcohol;