6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

Base Information

Chemical Name:6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile
CAS No.:1351943-50-4
Molecular Formula:C₂₆H₂₂ClN₅O₃
Molecular Weight:487.945
Hs Code.:

Synonyms:6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

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Chemical Property of 6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

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Technology Process of 6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

There total 12 articles about 6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.4%

: 1351942-60-3
4-(3-chloro-4(pyridin-2-yl-methoxy)phenylamino)-6-nitro-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351943-50-4
6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

Guidance literature:: With tin(II) chloride dihdyrate; In ethanol; at 85 ℃; for 1.5h;

Reference yield:

: 1351942-49-8
4-chloro-6-nitro-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351943-50-4
6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

2: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

With tin(II) chloride dihdyrate; pyridine hydrochloride; In ethanol; isopropyl alcohol;

Reference yield:

: 1351942-44-3
(E/Z)-ethyl 2-cyano-3-(4-nitro-3-(tetrahydrofuran-3-yl-oxy)-phenylamino)-acrylate

: 1351943-50-4
6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: biphenyl; diphenylether / 2 h / 256 °C / Inert atmosphere

2: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

3: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

4: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

With tin(II) chloride dihdyrate; pyridine hydrochloride; trichlorophosphate; In diphenylether; biphenyl; ethanol; isopropyl alcohol;