Technology Process of 3-(2-fluoro-4-(m-tolylethynyl)phenyl)propanoic acid
There total 6 articles about 3-(2-fluoro-4-(m-tolylethynyl)phenyl)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
DOI:10.1021/ml4000673
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydrogencarbonate; triphenylphosphine / water / 20 °C
2: sodium tetrahydroborate; cobalt(II) chloride / methanol / Inert atmosphere
3: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
4: potassium carbonate / 3 h / 20 °C
5: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
6: lithium hydroxide / water; tetrahydrofuran / 20 °C
With
sodium tetrahydroborate; copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; cobalt(II) chloride; lithium hydroxide; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane;
In
tetrahydrofuran; methanol; water;
1: |Wittig Olefination / 3: |Sonogashira Cross-Coupling / 5: |Sonogashira Cross-Coupling;
DOI:10.1021/ml4000673
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium tetrahydroborate; cobalt(II) chloride / methanol / Inert atmosphere
2: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
3: potassium carbonate / 3 h / 20 °C
4: sodium tetrachloropalladate(II); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine / water / 80 °C / Inert atmosphere
5: lithium hydroxide / water; tetrahydrofuran / 20 °C
With
sodium tetrahydroborate; copper(l) iodide; sodium tetrachloropalladate(II); N,N,N,N,-tetramethylethylenediamine; potassium carbonate; cobalt(II) chloride; lithium hydroxide; di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane;
In
tetrahydrofuran; methanol; water;
2: |Sonogashira Cross-Coupling / 4: |Sonogashira Cross-Coupling;
DOI:10.1021/ml4000673
