581778-88-3

Basic information

• Product Name: 2-Propenoic acid, 3-(4-bromo-2-fluorophenyl)-, ethyl ester, (2E)-
• CAS NO: 581778-88-3
• Molecular Formula: C11H10BrFO2
• Molecular Weight: 273.102
• Mol File: 581778-88-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(4-bromo-2-fluorophenyl)-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(4-bromo-2-fluorophenyl)-, ethyl ester, (2E)-(581778-88-3)
• EPA Substance Registry System: 2-Propenoic acid, 3-(4-bromo-2-fluorophenyl)-, ethyl ester, (2E)-(581778-88-3)

Safety Data

• Hazardous Substances Data: 581778-88-3(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 575469-65-7 3-(4-bromo-2-fluorophenyl)-2-propenoic acid 
• 105-36-2 ethyl bromoacetate 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 105931-73-5 1-bromo-3-fluoro-4-iodobenzene 
• 140-88-5 ethyl acrylate 

Downstream Products

• 1402602-05-4 ethyl (Z)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoate 
• 1402602-08-7 ethyl (E)-3-(2-fluoro-4-(5-hydroxy-3-methylpent-3-en-1-yn-1-yl)phenyl)propanoate 
• 1057674-14-2 ethyl 3-(4-bromo-2-fluorophenyl)propanoate 
• 1402601-97-1 methyl 3-(2-fluoro-4-(o-tolylethynyl)phenyl)propanoate 
• 1402601-81-3 3-(2-fluoro-4-(o-tolylethynyl)phenyl)propanoic acid 
• 1429427-42-8 methyl 3-(2-fluoro-4-(m-tolylethynyl)phenyl)propanoate 
• 1429427-33-7 3-(2-fluoro-4-(m-tolylethynyl)phenyl)propanoic acid 
• 1402601-93-7 methyl 3-(4-ethynyl-2-fluorophenyl)propanoate 
• 1402601-99-3 methyl 3-(4-((5-cyano-2-methylphenyl)ethynyl)-2-fluorophenyl)-propanoate 
• 1402601-83-5 3-(4-((5-cyano-2-methylphenyl)ethynyl)-2-fluorophenyl)propanoic acid 
• 1402602-07-6 methyl 3-(4-((2-(difluoromethyl)-5-fluorophenyl)ethynyl)-2-fluorophenyl)propanoate 
• 1402601-90-4 3-(4-((2-(difluoromethyl)-5-fluorophenyl)ethynyl)-2-fluorophenyl)propanoic acid 
• 1402602-06-5 methyl 3-(4-((3,5-dichlorophenyl)ethynyl)-2-fluorophenyl)propanoate 
• 1402601-89-1 3-(4-((3,5-dichlorophenyl)ethynyl)-2-fluorophenyl)propanoic acid 

Relevant articles and documents

A Simple and Efficient Access to Naphtho[b]furans by Claisen Rearrangement/Cyclization of Bromonaphthyl 3-Phenylallyl Ethers

A transition-metal-free Claisen rearrangement/cyclization reaction was developed for the synthesis of naphthofuran derivatives from bromonaphthyl 3-phenylallyl ethers. The nature of the base employed in this reaction plays an important role in determining the ratio for the formation of naphthofuran and naphthol products. By using K2CO3 as base and DMF as solvent, we have synthesized a variety of functionalized naphthofurans in good to high yields (49-92 %) and with satisfactory selectivities.

ORTHO-FLUORO SUBSTITUTED COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES

There is provided novel fluoro-substituted compounds capable of modulating the G- protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type II diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.