2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Base Information

Chemical Name:2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride
CAS No.:74291-57-9
Molecular Formula:C11H9 Cl F3 N O3 S
Molecular Weight:327.712
Hs Code.:2933499090
DSSTox Substance ID:DTXSID70462454
Nikkaji Number:J2.647.679H
Mol file:74291-57-9.mol

Synonyms:74291-57-9;2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride;1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONYL CHLORIDE;2-(2,2,2-trifluoroacetyl)-3,4-dihydro-1H-isoquinoline-7-sulfonyl Chloride;2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride;2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride;2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride;C11H9ClF3NO3S;SCHEMBL490066;DTXSID70462454;MFCD01075651;2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonylchloride;AKOS005168311;AS-36371;BP-11333;CS-0157265;FT-0606189;EN300-231900;A865922;2-trifluoroacetyl-7-chlorosulfonyl-1,2,3,4-tetrahydroisoquinoline;7-chlorosulfonyl-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline;1,2,3,4-tetrahydro-2-(trifluoroacetyl) isoquinoline-7-sulfonyl chloride;1,2,3,4-Tetrahydro-2-(trifluoroacetyl)isoquinoline -7-sulfonyl chloride;2-trifluoroacetyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride;2-Trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulphonyl chloride;-2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride;1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONYLCHLORIDE;2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride;2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinesulfonyl chloride, AldrichCPR

Suppliers and Price of 2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,2,3,4-Tetrahydro-2-(trifluoroacetyl)isoquinoline-7-sulfonylChloride
2.5g
$ 155.00

Matrix Scientific
2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride 98%
5g
$ 252.00

Matrix Scientific
2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride 98%
1g
$ 95.00

Matrix Scientific
2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride 98%
10g
$ 378.00

Crysdot
2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonylchloride 98%
25g
$ 372.00

Chemenu
2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonylchloride 95%+
25g
$ 352.00

ChemBridge Corporation
2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinesulfonylchloride 95%
250 mg
$ 44.00

American Custom Chemicals Corporation
1,2,3,4-TETRAHYDRO-2-(TRIFLUOROACETYL)ISOQUINOLINE-7-SULFONE 95.00%
1G
$ 721.59

Ambeed
2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonylchloride 98%
1g
$ 46.00

Ambeed
2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonylchloride 98%
25g
$ 540.00

Total 21 raw suppliers

Chemical Property of 2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Chemical Property:

Vapor Pressure:7.62E-09mmHg at 25°C
Melting Point:102-104°C
Boiling Point:465.6°C at 760 mmHg
PKA:-2.07±0.20(Predicted)
Flash Point:235.4°C
PSA：62.83000
Density:1.548g/cm³
LogP:3.07980
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Sensitive.:Moisture Sensitive
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:326.9943765
Heavy Atom Count:20
Complexity:488

Purity/Quality:

97% ^*data from raw suppliers

1,2,3,4-Tetrahydro-2-(trifluoroacetyl)isoquinoline-7-sulfonylChloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): R34:Causes burns.;
Hazard Codes:R34:Causes burns.;
Statements: 34
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC2=C1C=CC(=C2)S(=O)(=O)Cl)C(=O)C(F)(F)F
Uses 1,2,3,4-Tetrahydro-2-(trifluoroacetyl)isoquinoline-7-sulfonyl Chloride is an intermediate for the preparation of 5-heteroaryl thiazoles and their use as phosphoinositide 3-kinase (PI3K) inhibitors.

Technology Process of 2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

There total 8 articles about 2-(2,2,2-Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%