N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

Base Information

Chemical Name:N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide
CAS No.:1312594-80-1
Molecular Formula:C₂₁H₁₆BrClN₂O₂S₂
Molecular Weight:507.859
Hs Code.:

Synonyms:N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

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Chemical Property of N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

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Technology Process of N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

There total 6 articles about N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312594-78-7
2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-amine

: 2888-06-4
3-chlorophenylsulfonyl chloride

: 1312594-80-1
N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 585-74-0
3-Methylacetophenone

: 1312594-80-1
N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 70 °C / Inert atmosphere

2.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 1 h / 35 °C / Inert atmosphere

3.1: tin(IV) chloride / toluene / 4 h / Reflux; Inert atmosphere

4.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: water / ethanol / 2 h / 90 °C

5.2: pH ~ 7

5.3: 3 h / 200 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; water; tin(IV) chloride; sodium hydrogencarbonate; sulfur; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 901183-77-5
2-amino-4-(3-methylphenyl)-3-thiophenecarbonitrile

: 1312594-80-1
N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tin(IV) chloride / toluene / 4 h / Reflux; Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: water / ethanol / 2 h / 90 °C

3.2: pH ~ 7

3.3: 3 h / 200 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; water; tin(IV) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; toluene;