3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Base Information

Chemical Name:3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide
CAS No.:1312593-91-1
Molecular Formula:C₂₄H₁₉ClN₄O₂S₂
Molecular Weight:495.025
Hs Code.:

Synonyms:3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

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Chemical Property of 3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

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Technology Process of 3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

There total 7 articles about 3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 552846-17-0
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate

: 1312594-80-1
N-[2-bromo-6-methyl-3-(3-methylphenyl)thieno[2,3-b]pyridin-4-yl]-3-chlorobenzenesulfonamide

: 1312593-91-1
3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 120 ℃; for 0.5h; Inert atmosphere; microwave irradiation;

Reference yield:

: 585-74-0
3-Methylacetophenone

: 1312593-91-1
3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 70 °C / Inert atmosphere

2.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 1 h / 35 °C / Inert atmosphere

3.1: tin(IV) chloride / toluene / 4 h / Reflux; Inert atmosphere

4.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: water / ethanol / 2 h / 90 °C

5.2: pH ~ 7

5.3: 3 h / 200 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

7.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 0.5 h / 120 °C / Inert atmosphere; microwave irradiation

With N-Bromosuccinimide; water; tin(IV) chloride; sodium hydrogencarbonate; sodium carbonate; sulfur; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1312594-71-0
2-(1-(m-tolyl)ethylidene)malononitrile

: 1312593-91-1
3-chloro-N-[6-methyl-3-(3-methylphenyl)-2-(1H-pyrazol-4-yl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 1 h / 35 °C / Inert atmosphere

2.1: tin(IV) chloride / toluene / 4 h / Reflux; Inert atmosphere

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: water / ethanol / 2 h / 90 °C

4.2: pH ~ 7

4.3: 3 h / 200 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

6.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 0.5 h / 120 °C / Inert atmosphere; microwave irradiation

With N-Bromosuccinimide; water; tin(IV) chloride; sodium hydrogencarbonate; sodium carbonate; sulfur; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;