N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide

Base Information

Chemical Name:N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide
CAS No.:1598416-69-3
Molecular Formula:C₂₇H₃₀N₄O₃S
Molecular Weight:490.626
Hs Code.:

Synonyms:N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide

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Chemical Property of N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide

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Technology Process of N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide

There total 10 articles about N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1598417-38-9
4-[2-(3-amino-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-6-methoxy-quinoline-3-carbonitrile

: 133-59-5
Toluene-2-sulfonyl chloride

: 1598416-69-3
N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1598416-69-3
N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: ethanol / 4 h / 85 °C

2.1: Dowtherm A / 3 h / 250 °C

3.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

5.2: 2 h / 0 °C

6.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 80 °C

8.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 3 h / 20 °C

9.1: titanium(IV) isopropylate; ammonia / methanol / 0 - 20 °C

9.2: 2 h / 20 °C

10.1: triethylamine / dichloromethane / 0 - 20 °C

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; Dowtherm A; ammonia; phosphorus tribromide; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; sodium hydroxide; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 77156-78-6
ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate

: 1598416-69-3
N-(8-(2-(3-cyano-6-methoxyquinolin-4-yl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

3.2: 2 h / 0 °C

4.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 80 °C

6.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: titanium(IV) isopropylate; ammonia / methanol / 0 - 20 °C

7.2: 2 h / 20 °C

8.1: triethylamine / dichloromethane / 0 - 20 °C

With titanium(IV) isopropylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; ammonia; phosphorus tribromide; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; sodium hydroxide; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;