1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide

Base Information

Chemical Name:1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide
CAS No.:1346517-78-9
Molecular Formula:C₂₆H₂₄ClFN₂O₃S
Molecular Weight:499.006
Hs Code.:

Synonyms:1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide

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Chemical Property of 1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide

Chemical Property:

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Technology Process of 1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide

There total 8 articles about 1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1346518-04-4
[1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl]acetic acid

: 39191-07-6
3-chloro-N-methylbenzylamine

: 1346517-78-9
1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1346517-78-9
1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.25 h / 20 °C

2.1: Oxone / dichloromethane / 48 h / 20 °C

3.1: hydrogenchloride / butanone; water / 2 h / 20 °C

3.2: 80 °C

4.1: tetrahydrofuran / 20 °C / Inert atmosphere

5.1: sodium tetrahydroborate / dichloromethane; water; methanol / 0.25 h / -40 °C

5.3: pH 8

6.1: triphenylphosphine; iodine / toluene / 1 h / 80 °C

7.1: sodium hydroxide; water / methanol / 2 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

With hydrogenchloride; Oxone; sodium tetrahydroborate; water; iodine; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; butanone;

Reference yield:

: 1346517-96-1
1-(3-fluorobenzylsulfonyl)-2-methylindolizine

: 1346517-78-9
1-(3-fluorobenzylsulfonyl)-2-methylindolizin-3-yl-N-(3-chlorobenzyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / dichloromethane; water; methanol / 0.25 h / -40 °C

2.3: pH 8

3.1: triphenylphosphine; iodine / toluene / 1 h / 80 °C

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

With sodium tetrahydroborate; water; iodine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;