2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide

Base Information

Chemical Name:2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide
CAS No.:929561-90-0
Molecular Formula:C₁₉H₁₈Cl₂N₄O₂S
Molecular Weight:437.35
Hs Code.:

Synonyms:2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide

Chemical Property:

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Technology Process of 2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide

There total 5 articles about 2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: C₁₆H₁₁Cl₂N₃O₂S*(x)ClH

: 109-85-3
2-methoxyethylamine

: 929561-90-0
2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 929561-90-0
2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanide / N,N-dimethyl-formamide / 4.17 h / Reflux

2: bromine / ethanol / 7 h / 20 °C / Reflux

3: ethanol / 2 h / Reflux

4: hydrogenchloride / 1,4-dioxane; water / 50 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; bromine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium cyanide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 929562-43-6
C₁₃H₁₇NO₃

: 929561-90-0
2-[(2,5-dichlorophenyl)amino]-N-(2-methoxyethyl)-4-(4-pyridinyl)-5-thiazoleacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / ethanol / 7 h / 20 °C / Reflux

2: ethanol / 2 h / Reflux

3: hydrogenchloride / 1,4-dioxane; water / 50 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; bromine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;