(S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

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Chemical Name:(S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
CAS No.:1597531-24-2
Molecular Formula:C₃₀H₃₈N₆O₃Si
Molecular Weight:558.756
Hs Code.:

Synonyms:(S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

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Chemical Property of (S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

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Technology Process of (S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

There total 6 articles about (S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carboxylic acid

: 1597531-22-0
2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-N-hydroxybenzamidine

: 1597531-24-2
(S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: (S)-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)pyrrolidine-2-carboxylic acid; 2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-N-hydroxybenzamidine; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

In 1,4-dioxane; at 80 ℃; for 18h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1597531-24-2
(S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / tetrahydrofuran / 18 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 48 h / 65 °C

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 18 h / 20 °C

3.2: 18 h / 80 °C

With 1H-imidazole; hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: (S)-1-(5-methyl-2-[1,2,3]triazol-2-yl-benzoyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1597531-24-2
(S)-(2-(3-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 18 h / 20 °C

2.2: 18 h / 80 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;