2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel
CAS No.:160768-77-4
Molecular Formula:C₅₁H₇₁NO₁₃Si₂
Molecular Weight:962.295
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

Suppliers and Price of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

There total 9 articles about 2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 530-62-1
1,1'-carbonyldiimidazole

: 160768-75-2
2'-O-(tert-butyldimethylsilyl)-4-O-deacetyl-2-O-debenzoyl-7-O-(triethylsilyl)paclitaxel

: 160768-77-4
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

Guidance literature:: In tetrahydrofuran; at 55 ℃; for 6h;
DOI:10.1016/0040-4039(94)88392-0

Reference yield: 83.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 160768-75-2
2'-O-(tert-butyldimethylsilyl)-4-O-deacetyl-2-O-debenzoyl-7-O-(triethylsilyl)paclitaxel

: 160768-77-4
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

Guidance literature:: In pyridine; Ambient temperature;
DOI:10.1016/0040-4039(94)85019-4

Reference yield:

: 156413-61-5
2'-(tert-butyldimethylsilyl)-7-(triethylsilyl)paclitaxel

: 160768-77-4
2'-O-(tert-butyldimethylsilyl)-7-O-triethylsilyl-2-debenzoyl-4-deacetyl-1,2-carbonato-paclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / Triton B / CH₂Cl₂; methanol / 2 h / -15 - -10 °C

2: 85 percent / CH₂Cl₂ / 24 h / 35 - 40 °C

With N-benzyl-trimethylammonium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jo982095h