N^δ-benzyloxycarbonyl-N^α-(N-benzyloxycarbonyl-valyl)-ornithine methyl ester

Base Information

• Chemical Name: N^δ-benzyloxycarbonyl-N^α-(N-benzyloxycarbonyl-valyl)-ornithine methyl ester
• CAS No.: 4864-40-8
• Molecular Formula: C₂₇H₃₅N₃O₇
• Molecular Weight: 513.591
• Mol file: 4864-40-8.mol

Synonyms:N^δ-benzyloxycarbonyl-N^α-(N-benzyloxycarbonyl-valyl)-ornithine methyl ester

Chemical Property of N^δ-benzyloxycarbonyl-N^α-(N-benzyloxycarbonyl-valyl)-ornithine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^δ-benzyloxycarbonyl-N^α-(N-benzyloxycarbonyl-valyl)-ornithine methyl ester

There total 6 articles about N^δ-benzyloxycarbonyl-N^α-(N-benzyloxycarbonyl-valyl)-ornithine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (S)-(1-hydrazineyl-3-methyl-1-oxobutan-2-yl)carbamate (2443-71-2) → Nδ-benzyloxycarbonyl-Nα-(N-benzyloxycarbonyl-valyl)-ornithine methyl ester (4864-40-8)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; at 0 ℃; N^δ-benzyloxycarbonyl-N^α-<N-benzyloxycarbonyl-L-valyl>-(Ξ)-ornithine methyl ester; Umsetzung des gebildeten Azids mit N^δ-Benzyloxycarbonyl-DL-ornithin-methylester in Aethylacetat;

DOI:10.1038/161804b0

Reference yield:

Z-(S)-Val-Cl (87052-60-6) → Nδ-benzyloxycarbonyl-Nα-(N-benzyloxycarbonyl-L-valyl)-L-ornithine methyl ester (4864-40-8)

Guidance literature:

With diethyl ether; potassium hydrogencarbonate; ethyl acetate;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → Nδ-benzyloxycarbonyl-Nα-(N-benzyloxycarbonyl-L-valyl)-L-ornithine methyl ester (4864-40-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous NaOH

2: diethyl ether; PCl₅

3: aqueous KHCO₃; diethyl ether; ethyl acetate

With sodium hydroxide; diethyl ether; phosphorus pentachloride; potassium hydrogencarbonate; ethyl acetate;

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

methyl (2S)-2-amino-5-[[(benzyloxy)carbonyl]amino]pentanoate hydrochloride

Z-(S)-Val-Cl

L-valine

Downstream raw materials:

Z-L-Val-δ-Z-L-Orn-OH