Technology Process of 2-<2'-(phenylthio)ethyl>-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole
There total 10 articles about 2-<2'-(phenylthio)ethyl>-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 2.5h;
DOI:10.1021/jo00027a016
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) triethylamine / 1.) methylene dichloride, 0 deg C, 2 h 2.) THF, 25 deg C, 12 h
2: 100 percent / sodium borohydride / methanol / 1 h / 21 °C
3: 96 percent / trifluoroacetic acid / CH2Cl2 / 2.5 h / 0 °C
With
sodium tetrahydroborate; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane;
DOI:10.1021/jo00027a016
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 73 percent / aq. acetic acid / 10 h / Heating
2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C
3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H2O / 2 h / 0 °C
4: tetra-N-benzylammonium chloride, 30percent NaOH / CH2Cl2 / 1 h
5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C
6: 1.) triethylamine / 1.) methylene dichloride, 0 deg C, 2 h 2.) THF, 25 deg C, 12 h
7: 100 percent / sodium borohydride / methanol / 1 h / 21 °C
8: 96 percent / trifluoroacetic acid / CH2Cl2 / 2.5 h / 0 °C
With
hydrogenchloride; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; Bn4NCl; dimethoxypropane; acetic acid; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00027a016
![2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-N-(2-phenylsulfanyl-ethyl)-acetamide](/Databaselist/images/loading.webp)
