2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester

Base Information

• Chemical Name: 2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester
• CAS No.: 187337-13-9
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Mol file: 187337-13-9.mol

Synonyms:2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester

Chemical Property of 2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester

There total 3 articles about 2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-oxobutyric acid 3-phenylprop-2-ynyl ester (57727-97-6) + propargyl bromide (106-96-7) → 2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester (187337-13-9)

Guidance literature:

3-oxobutyric acid 3-phenylprop-2-ynyl ester; With sodium hydride; In tetrahydrofuran; at 25 ℃; for 0.5h;

propargyl bromide; In tetrahydrofuran; toluene; at 60 ℃; for 4h; Further stages.;

DOI:10.1021/jo991938h

Reference yield:

3-Phenyl-2-propyn-1-ol (1504-58-1) → 2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester (187337-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / xylene / 2 h / 140 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 25 °C

2.2: 60 percent / tetrahydrofuran; toluene / 4 h / 60 °C

With sodium hydride; In tetrahydrofuran; xylene; 1.1: Ring cleavage / 2.1: Metallation / 2.2: Alkylation;

DOI:10.1021/jo991938h

Reference yield:

3-oxobutyric acid 3-phenylprop-2-ynyl ester (57727-97-6) → 2-acetylpent-4-ynoic acid 3-phenylprop-2-ynyl ester (187337-13-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) THF, 25 deg C, 30 min, 2) THF, 60 deg C, 4 h;

DOI:10.1055/s-1997-740

upstream raw materials:

3-oxobutyric acid 3-phenylprop-2-ynyl ester

propargyl bromide

3-Phenyl-2-propyn-1-ol